The Medicine and Healthcare products Regulatory Agency (MHRA) Central Alerting System (CAS) is the national system for issuing patient safety alerts, important public health messages and other safety-critical information to all providers, including GP practices. From 1 October 2019, MHRA will send CAS alerts directly to GP practices, replacing any local arrangements currently in place. All GP practices in England are contractually required to register to receive CAS alerts directly from the MHRA by accessing this link to the portal. Registration is recommended to be completed by 13 September 2019 to allow sufficient time for registration checks and testing.